![]() ![]() investigated electrodermal responses to auditory stimuli in children with autism and found that many of these children lacked autonomic responses to the first acoustic event in a series, but once responding they demonstrated high amplitude electrodermal responses. On the other hand, hypersensitivity to sound or hyperacusis is also a very common problem in ASD and may even require therapeutic intervention. Parents of ASD children may suspect hearing impairment or hearing loss in their children during the first two years of life, because of their striking unresponsiveness to sound. In many cases sensory abnormalities are especially noticeable in the auditory domain. ![]() They cover different sensory domains and may manifest as both hyper- and hyposensitivity to stimulation. Sensory difficulties are observed in both high- and low-functioning ASD individuals and are prominent from the first years of life, through childhood, , and during adulthood. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.Īpart from the ‘core’ deficits central to a diagnosis of autism, such as abnormal social interaction, communication and presence of repetitive behaviors, individuals with autism spectrum disorders (ASD) frequently demonstrate a range of sensory abnormalities. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: This research was supported by grant # 2009-3765 from the Swedish Research Council and by grant # 16.5 from the Russian Ministry of Science and Education. Received: MaAccepted: Published: June 29, 2012Ĭopyright: © 2012 Orekhova et al. PLoS ONE 7(6):Įditor: Christina Schmitz, Centre Hospitalier Le Vinatier (Bât. (2012) Auditory Cortex Responses to Clicks and Sensory Modulation Difficulties in Children with Autism Spectrum Disorders (ASD). The correlation of sensory abnormalities with atypical, more leftward, P100m lateralization suggests that reduced preattentive processing in the right hemisphere and/or its shift to the left hemisphere may contribute to abnormal sensory behavior in ASD.Ĭitation: Orekhova EV, Tsetlin MM, Butorina AV, Novikova SI, Gratchev VV, Sokolov PA, et al. The absence of right-hemispheric predominance of the P100m and a tendency for its right-hemispheric reduction in the ASD children suggests disturbance of the RH ascending reticular brainstem pathways and/or their thalamic and cortical projections, which in turn may contribute to abnormal arousal and attention. The atypical P100m lateralization in the ASD subjects was associated with greater severity of sensory abnormalities assessed by Short Sensory Profile, as well as with auditory hypersensitivity during the first two years of life. The P100m was rightward lateralized in the TD, but not in the ASD children, who showed a tendency toward P100m reduction in the right hemisphere (RH). We further analyzed the P100m, which is the most prominent component of the auditory magnetic field response in children and may reflect preattentive arousal processes. ![]() To study neurophysiological correlates of the sensory modulation difficulties, we recorded magnetic field responses to clicks in 14 ASD and 15 typically developing (TD) children. Auditory sensory modulation difficulties are common in autism spectrum disorders (ASD) and may stem from a faulty arousal system that compromises the ability to regulate an optimal response.
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